解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract:BACKGROUND:It has been suggested that the B-cell specific moloney leukemia virus insertion site 1 (Bmi-1) gene plays an oncogenic role in several types of human cancer, but the status of Bmi-1 amplification and expression in ovarian cancer and its clinical/prognostic significance are unclear. METHODS:The methods of im...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-10-133
更新日期:2010-04-08 00:00:00
abstract:BACKGROUND:Gastric cancer peritoneal carcinomatosis is a common clinical problem, but there are no suitable large animal models to study this problem. This study was to establish a stable rabbit peritoneal carcinomatosis model of gastric cancer using VX2 tumor, and analyze the clinico-pathological features. METHODS:VX...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-10-124
更新日期:2010-04-01 00:00:00
abstract:BACKGROUND:Over-expression of HER2 in a subset of breast cancers (HER2+) is associated with high histological grade and aggressive clinical course. Despite these distinctive features, the differences in response of HER2+ patients to both adjuvant cytotoxic chemotherapy and targeted therapy (e.g. trastuzumab) suggests t...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-10-108
更新日期:2010-03-22 00:00:00
abstract:BACKGROUND:The objective of this retrospective study is to investigate laryngeal preservation and long-term treatment results in hypopharyngeal carcinoma treated with intensity-modulated radiotherapy (IMRT) combined with chemotherapy. METHODS:Twenty-seven patients with hypopharyngeal carcinoma (stage II-IV) were enrol...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-10-102
更新日期:2010-03-18 00:00:00
abstract:BACKGROUND:Ovarian carcinoma is a rarely curable disease, for which new treatment options are required. As agents that block HMG-CoA reductase and the mevalonate pathway, the statin family of drugs are used in the treatment of hypercholesterolemia and have been shown to trigger apoptosis in a tumor-specific manner. Rec...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-10-103
更新日期:2010-03-18 00:00:00
abstract:BACKGROUND:The VEGF family of ligands and receptors are intimately involved in tumor angiogenesis, lymphangiogenesis and metastasis. The evaluation of VEGF ligand/receptor ratios may provide a more profound understanding of the involvement of these proteins in colorectal tumour progression. The aim of this study was to...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-10-93
更新日期:2010-03-11 00:00:00
abstract:BACKGROUND:HAX-1 has been described as a protein potentially involved in carcinogenesis and especially metastasis. Its involvement in regulation of apoptosis and cell migration along with some data indicating its overexpression in cancer cell lines and tumors suggests that HAX-1 may play a role in neoplastic transforma...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-10-76
更新日期:2010-03-02 00:00:00
abstract:BACKGROUND:The short arm of human chromosome 3 is involved in the development of many cancers including lung cancer. Three bona fide lung cancer tumor suppressor genes namely RBSP3 (AP20 region),NPRL2 and RASSF1A (LUCA region) were identified in the 3p21.3 region. We have shown previously that homozygous deletions in A...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-10-75
更新日期:2010-03-01 00:00:00
abstract:BACKGROUND:Ovarian epithelial cancer (OEC) usually presents in the later stages of the disease. Factors, especially those associated with cell-cycle genes, affecting the genesis and tumour progression for ovarian cancer are largely unknown. We hypothesized that over-expressed transcription factors (TFs), as well as tho...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-10-64
更新日期:2010-02-24 00:00:00
abstract:BACKGROUND:We have recently described the correlation between quantitative measures of HER2 expression or HER2 homodimers by the HERmark assay and objective response (RR), time-to progression (TTP), and overall survival (OS) in an expanded access cohort of trastuzumab-treated HER2-positive patients with metastatic brea...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-10-56
更新日期:2010-02-23 00:00:00
abstract:BACKGROUND:The prognosis for patients with recurrent glioblastoma is still poor with a median survival between 3 and 6 months. Reports about the application of carmustine (BCNU), one of the standard chemotherapeutic drugs in the treatment of newly diagnosed glioblastoma, in the recurrent situation are rare. METHODS:We...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-10-30
更新日期:2010-02-02 00:00:00
abstract:BACKGROUND:Combinations of trastuzumab with either docetaxel or vinorelbine are considered valuable treatment options for HER2-positive metastatic breast cancer patients. We performed a retrospective comparison of the clinical outcomes associated with either one of these combinations. METHODS:From a multi-institutiona...
journal_title:BMC cancer
pub_type: 杂志文章,多中心研究
doi:10.1186/1471-2407-10-28
更新日期:2010-02-01 00:00:00
abstract:BACKGROUND:In Australia, associations between geographic remoteness, socioeconomic disadvantage, and colorectal cancer (CRC) survival show that survival rates are lowest among residents of geographically remote regions and those living in disadvantaged areas. At present we know very little about the reasons for these i...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-10-24
更新日期:2010-01-28 00:00:00
abstract:BACKGROUND:S100 calcium binding protein A8 (S100A8) has been implicated as a prognostic indicator in several types of cancer. However, previous studies are limited in their ability to predict the clinical behavior of the cancer. Here, we sought to identify a molecular signature based on S100A8 expression and to assess ...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-10-21
更新日期:2010-01-25 00:00:00
abstract:BACKGROUND:About 5-10% of breast cancer is due to inherited disease predisposition. Many previously identified susceptibility factors are involved in the maintenance of genomic integrity. AATF plays an important role in the regulation of gene transcription and cell proliferation. It induces apoptosis by associating wit...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-9-457
更新日期:2009-12-21 00:00:00
abstract:BACKGROUND:We evaluated the hierarchical risk groups for the estimated survival of WHO grade III glioma patients using recursive partitioning analysis (RPA). To our knowledge, this is the first study to address the results of RPA specifically for WHO grade III gliomas. METHODS:A total of 133 patients with anaplastic a...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-9-450
更新日期:2009-12-18 00:00:00
abstract:BACKGROUND:Human papillomaviruses (HPV) are the aetiological agents of certain benign and malignant tumours of skin and mucosae; the most important of which is cervical cancer. Also, the incidence of ano-genital warts, HPV-anal cancer and oropharyngeal cancers are rising. To help ascertain a useful PCR detection protoc...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-9-440
更新日期:2009-12-15 00:00:00
abstract:BACKGROUND:Rhabdoid tumors are rare cancers of early childhood arising in the kidney, central nervous system and other organs. The majority are caused by somatic inactivating mutations or deletions affecting the tumor suppressor locus SMARCB1 [OMIM 601607]. Germ-line SMARCB1 inactivation has been reported in associatio...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-9-437
更新日期:2009-12-13 00:00:00
abstract:BACKGROUND:B7-H4, a co-inhibitory molecule of the B7 family, can restrain T cell proliferation, cytokine secretion and the development of cytotoxicity. B7-H4 is expressed in tumor tissues at a higher level than in normal tissues, and has a potential effect to protect tumors from anti-tumor immune responses. This case-c...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-9-394
更新日期:2009-11-11 00:00:00
abstract:BACKGROUND:Loss of DNA mismatch repair (MMR) in humans, mainly due to mutations in the hMLH1 gene, is linked to hereditary nonpolyposis colorectal cancer (HNPCC). Because not all MLH1 alterations result in loss of MMR function, accurate characterization of variants and their classification in terms of their effect on M...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-9-382
更新日期:2009-10-28 00:00:00
abstract:BACKGROUND:The transient receptor potential, subfamily V, member 6 (TRPV6) is a Ca(2+) selective cation channel. Several studies have shown that TRPV6 transcripts are expressed in locally advanced prostatic adenocarcinoma, metastatic and androgen-insensitive prostatic lesions but are undetectable in healthy prostate ti...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-9-380
更新日期:2009-10-26 00:00:00
abstract:BACKGROUND:Gambogic acid (GA) is a major active ingredient of gamboge, a widely used traditional Chinese medicine that has been reported to be a potent cytotoxic agent against some malignant tumors. Many studies have shown that the NF-kappa B signaling pathway plays an important role in anti-apoptosis and the drug resi...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-9-343
更新日期:2009-09-25 00:00:00
abstract:BACKGROUND:Thymidylate synthase (TS) and Topoisomerase I (Topo I) are significant biomarkers in colorectal cancer (CRC). We aimed to study the expression of TS and Topo I in patients with resected CRC who received adjuvant chemotherapy and correlated it with clinical outcome. METHODS:All patients diagnosed with CRC be...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-9-339
更新日期:2009-09-24 00:00:00
abstract:BACKGROUND:Although Temozolomide is effective against glioblastoma, the prognosis remains dismal and new regimens with synergistic activity are sought for. METHODS:In this phase-I/II trial, pegylated liposomal doxorubicin (Caelyx, PEG-Dox) and prolonged administration of Temozolomide in addition to radiotherapy was in...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-9-308
更新日期:2009-09-02 00:00:00
abstract:BACKGROUND:Interpretation of comparative health-related quality of life (HRQOL) studies following different prostate cancer treatments is often difficult due to differing patient ages. Furthermore, age-related changes can hardly be discriminated from therapy-related changes. The evaluation of age-and comorbidity-relate...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-9-296
更新日期:2009-08-24 00:00:00
abstract:BACKGROUND:SET domain containing protein 2 (SETD2) is a histone methyltransferase that is involved in transcriptional elongation. There is evidence that SETD2 interacts with p53 and selectively regulates its downstream genes. Therefore, it could be implicated in the process of carcinogenesis. Furthermore, this gene is ...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-9-290
更新日期:2009-08-21 00:00:00
abstract:BACKGROUND:The aim of this study was to determine influence of prognostic factors in addition to UICC staging systems, on cancer-specific and overall survival rates for patients with colorectal cancer (CRC) undergoing surgical treatment. METHODS:Between January 1996 and December 2006, a total of 1367 CRC patients who ...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-9-288
更新日期:2009-08-20 00:00:00
abstract:BACKGROUND:Needle core biopsy, often in conjunction with ultrasonic or stereotactic guided techniques, is frequently used to diagnose breast carcinoma in women. Confocal scanning laser microscopy (CSLM) is a technology that provides real-time digital images of tissues with cellular resolution. This paper reports the pr...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-9-265
更新日期:2009-08-03 00:00:00
abstract:BACKGROUND:Metastatic melanoma is an incurable disease with an average survival of less than one year. Talabostat is a novel dipeptidyl peptidase inhibitor with immunostimulatory properties. METHODS:This phase II, open label, single arm study was conducted to evaluate the safety and efficacy of 75-100 mg/m2 cisplatin ...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-9-263
更新日期:2009-07-30 00:00:00
abstract:BACKGROUND:Twist, a transcription factor of the basic helix-loop-helix class, is reported to regulate cancer metastasis. It is known to induce epithelial-mesenchymal transition (EMT). In this study, we evaluated the expression of twist and its effect on cell migration in hepatocellular carcinoma (HCC). METHODS:We exam...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-9-240
更新日期:2009-07-18 00:00:00
abstract:BACKGROUND:Recent reports indicate the existence of breast cancer cells expressing very high levels of the Arylhydrocarbon receptor (AhR), a ubiquitous intracellular receptor best known for mediating toxic action of dioxin and related pollutants. Positive correlation between the degree of AhR overexpression and states ...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-9-234
更新日期:2009-07-15 00:00:00
abstract:BACKGROUND:The treatment of the primary tumor in advanced metastatic colorectal cancer (CRC) is still a matter of discussion. Little attention has thus far been paid to the endoscopically observable changes of the primary in non-curatively resectable stage IV disease. METHODS:20 patients [14 men, 6 women, median age 6...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-9-218
更新日期:2009-07-01 00:00:00
abstract:BACKGROUND:Previous study reported that resveratrol has anti-tumor activity. In this study, we investigated the involvement of autophagy in the resveratrol-induced apoptotic death of human U251 glioma cells. METHODS:The growth inhibition of U251 cells induced by resveratrol was assessed with methyl thiazolyl tetrazoli...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-9-215
更新日期:2009-06-30 00:00:00
abstract:BACKGROUND:New therapeutic principles in clinical oncology require the adjustment of response criteria to govern therapy decisions. For advanced hepatocellular carcinoma (HCC) a new era has recently begun by the approval of the multikinase inhibitor sorafenib. As a unique feature, HCC usually develops in a diseased liv...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-9-208
更新日期:2009-06-28 00:00:00
abstract:BACKGROUND:Clinical trials where cancer patients were treated with protease inhibitors have suggested that the serine protease, prostasin, may act as a tumour suppressor. Prostasin is proteolytically activated by the serine protease, matriptase, which has a very high oncogenic potential. Prostasin is inhibited by prote...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-9-201
更新日期:2009-06-25 00:00:00
abstract:BACKGROUND:MicroRNAs are the endogenous small non-coding RNA molecules capable of silencing protein coding genes at the posttranscriptional level. Based on computer-aided predictions, a single microRNA could have over a hundred of targets. On the other hand, a single protein-coding gene could be targeted by many potent...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-9-194
更新日期:2009-06-18 00:00:00
abstract:BACKGROUND:Cationic antimicrobial peptides (CAPs) with antitumor activity constitute a promising group of novel anticancer agents. These peptides induce lysis of cancer cells through interactions with the plasma membrane. It is not known which cancer cell membrane components influence their susceptibility to CAPs. We h...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-9-183
更新日期:2009-06-15 00:00:00
abstract:BACKGROUND:The Nijmegen Breakage Syndrome is a chromosomal instability disorder characterized by microcephaly, growth retardation, immunodeficiency, and increased frequency of cancers. Familial studies on relatives of these patients indicated that they also appear to be at increased risk of cancer. METHODS:In a candid...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-9-181
更新日期:2009-06-12 00:00:00
abstract:BACKGROUND:Kaiso has been identified as a new member of the POZ-zinc finger family of transcription factors that are implicated in development and cancer. Although controversy still exists, Kaiso is supposed to be involved in human cancer. However, there is limited information regarding the clinical significance of cyt...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-9-178
更新日期:2009-06-09 00:00:00
abstract:BACKGROUND:To investigate the diagnostic reliability of selective microdochectomy after direct ductoscopic wire marking of suspect lesions in patients with pathological nipple discharge. METHODS:Selective microdochectomy due to pathological discharge was performed in 33 patients with mean age of 51.7 years. Ductoscope...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-9-151
更新日期:2009-05-17 00:00:00